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oai:docta.ucm.es:20.500.14352/1238802025-09-13T00:22:41Zcom_20.500.14352_14col_20.500.14352_15

Affinity bioelectroanalysis in cellular-level biomarker driven modern precision cancer diagnosis Campuzano Ruiz, Susana Gamella Carballo, María Pedrero Muñoz, María Pingarrón Carrazón, José Manuel 543 Affinity biosensing Electrochemical Cells Secretomes Exosomes Cancer Precision diagnosis Ciencias 23 Química The increasingly prominent role played by precision, equitable and sustainable diagnosis, particularly of prevalent and highly heterogeneous diseases, based on the determination and characterization of biomarkers of cellular origin in liquid biopsy, such as whole cells, their secretomes and the exosomes they release, is unquestionable. Electrochemical biosensing and biosensors, mainly those involving affinity reactions, have emerged in recent years as competitive analytical alternatives to address these challenging targets versus other existing strategies in terms of simplicity, cost and compatibility with multiplexed or multi-omics point-of-care determinations. This review article aims to put on the table in a concise, accurate and updated way the fundamentals, versatility and opportunities provided by state-ofthe-art electrochemical biosensing (2018e2022) for the determination of these cellular-derived biomarkers. A more critical and personal view of the challenges to be faced in the shorter term and where future research and advances are expected to go is also given. Ministerio de Ciencia, Innovación y Universidades Comunidad de Madrid Depto. de Química Analítica Fac. de Ciencias Químicas TRUE pub 2025-09-12T09:26:03Z 2025-09-12T09:26:03Z 2023-04-15 journal article VoR https://hdl.handle.net/20.500.14352/123880 XXXX-XXXX 10.1016/j.trac.2023.117064 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-103899RB-I00/ES/BIOSENSORES PARA DESENTRAÑAR EL LEGADO Y EL FUTURO DE LA EPIGENETICA Y LA METASTASIS DEL CANCER/ S2018/NMT-4349 TRANSNANOAVANSENS-CM Program Susana Campuzano, Maria Gamella, María Pedrero, José M. Pingarrón, Affinity bioelectroanalysis in cellular-level biomarker driven modern precision cancer diagnosis, TrAC Trends in Analytical Chemistry, Volume 163, 2023, 117064, ISSN 0165-9936, https://doi.org/10.1016/j.trac.2023.117064. open access application/pdf Elsevier