2026-06-28T20:31:31Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1247492025-10-09T23:57:18Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Lira-Mejía, Boris author Calderon-Romero, Roger author Ordaya-Fierro, Jorge author Medina, Cristian author Rodríguez, José-Luis author Romero Martínez, Manuel Alejandro author Dávila, Roberto author Ramos-Gonzalez, Mariella 2025-10-09T14:20:57Z 2025-10-09T14:20:57Z 2025 Lira-Mejía, B., Calderon-Romero, R., Ordaya-Fierro, J., Medina, C., Rodríguez, J. L., Romero, A., Dávila, R., & Ramos-Gonzalez, M. (2025). Impact of Exposure Duration to High-Altitude Hypoxia on Oxidative Homeostasis in Rat Brain Regions. International journal of molecular sciences, 26(17), 8714. https://doi.org/10.3390/ijms26178714 1661-6596 10.3390/ijms26178714 https://hdl.handle.net/20.500.14352/124749 1422-0067 https://doi.org/10.3390/ijms26178714 40943633 Hypoxia at altitudes above 3000 m poses a significant threat to organ health and physiological homeostasis, particularly in metabolically active tissues such as the brain. Many of the cellular alterations induced by hypoxia are associated with the excessive generation of reactive oxygen species (ROS) and the resulting oxidative stress. In this study, we investigated the effects of exposure duration and altitude levels on oxidative homeostasis in the rat hypothalamus, cortex, hippocampus, and striatum. We assessed ROS production, malondialdehyde (MDA) levels, the antioxidant activities of superoxide dismutase (SOD), and catalase, as well as molecular biomarkers of oxidative stress, cell death, and inflammation. Our findings demonstrated that ROS, MDA and SOD levels increased across all brain regions, particularly in response to higher altitude exposure. Conversely, catalase activity decreased under the same conditions. At the molecular level, we observed overexpression of key biomarkers related to oxidative stress, cell death, and inflammation, especially at extreme altitudes. Furthermore, these effects were most pronounced in the hippocampus, cortex, and striatum. In conclusion, our data indicate that hypoxic exposure at higher altitudes significantly contributes to the oxidative disruption of brain homeostasis in rats eng Attribution 4.0 International Impact of Exposure Duration to High-Altitude Hypoxia on Oxidative Homeostasis in Rat Brain Regions journal article 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URL https://docta.ucm.es/bitstreams/aa526d52-4fd1-4d30-9ddc-9a21d0cf75bc/download File MD5 932c41d1e820786b82d0b1182c0e87ca 2031729 application/pdf Impact of Exposure Duration.pdf