2026-06-08T09:11:31Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1248372025-10-13T23:51:04Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Ye, Xiaochun author Zhao, Yongxia author Ma, Wanqing author Ares Lombán, Irma author Martínez Caballero, Marta author López Torres, Bernardo author Martínez Larrañaga, María Rosa author Wang, Xu author Anadón Navarro, Arturo Ramón author Martínez Caballero, María Aranzazu author 2023 Cluster of differentiation 38 (CD38) is a multifunctional cell surface protein involved in nicotinamide adenine dinucleotide (NAD+) homeostasis in types of cells and tissues, which can be found in many immune cells and non-immune cells. Previous studies have shown that CD38 plays an important role in regulating innate immunity. Recently, many studies have revealed the importance of CD38 in autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), type 1 diabetes (T1D) and inflammatory bowel disease, among others. In this report, we will briefly discuss the complex immunological functions of CD38 and focus on recent advances in the role of CD38 in the development and pathogenesis of autoimmune diseases, as well as their potential as therapeutic targets for systemic diseases, intending to make a comprehensive understanding of CD38 and its promising therapeutic potential in these systemic diseases Ye, X., Zhao, Y., Ma, W., Ares, I., Martínez, M., Lopez-Torres, B., Martínez-Larrañaga, M. R., Wang, X., Anadón, A., & Martínez, M. A. (2023). The potential of CD38 protein as a target for autoimmune diseases. Autoimmunity reviews, 22(4), 103289. https://doi.org/10.1016/j.autrev.2023.103289 1568-9972 https://doi.org/10.1016/j.autrev.2023.103289 https://hdl.handle.net/20.500.14352/124837 1873-0183 https://doi.org/10.1016/j.autrev.2023.103289 36750136 The potential of CD38 protein as a target for autoimmune diseases