2026-06-08T13:39:06Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1252502025-10-22T23:55:09Zcom_20.500.14352_14col_20.500.14352_15

Ruano, Jessica Louzame Bejarano, Leire Serrano, Rosa Diaz, Ruth Alvarez Flores Landeira, Juana María López, Ana Cayuela Blasco, Maria A. 2025-10-22T12:53:47Z 2025-10-22T12:53:47Z 2025 Ruano, J. L., Bejarano, L., Serrano, R., Diaz, R. A., Flores, J. M., López, A. C., & Blasco, M. A. (2025). Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles. Aging, 17(9), 2410–2429. https://doi.org/10.18632/aging.206320 10.18632/aging.206320 https://hdl.handle.net/20.500.14352/125250 1945-4589 https://doi.org/10.18632/aging.206320 40982211 TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles journal article