2026-06-08T09:51:44Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1252502025-10-22T23:55:09Zcom_20.500.14352_14col_20.500.14352_15

Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles Ruano, Jessica Louzame Bejarano, Leire Serrano, Rosa Diaz, Ruth Alvarez Flores Landeira, Juana María López, Ana Cayuela Blasco, Maria A. 636.09 Trf1 Fat Leaner Metabolism Telomeres Veterinaria 3109 Ciencias Veterinarias Author Contributions: MAB, JL and LB had the original idea. MAB secured funding and supervised the research. JL analyzed the results, wrote the paper and performed the experiments. RS was responsible for animal maintenance and assisted with animal experimentation. JMF performed pathological analysis. ACL developed and analyzed the confocal microscopy images, and RAD performed the bioinformatics analysis. TRF1, a component of the telomere shelterin complex, plays crucial roles in telomere protection, telomere length regulation, and stemness. Here, we describe a previously unknown connection between TRF1 and metabolism. Telomere attrition has been linked to obesity. Our study reveals that Trf1-deficient mice exhibit a leaner phenotype, reduced adiposity, and improved glucose tolerance, even when subjected to a high-fat diet, independently of telomere shortening. These findings uncover a previously unknown role of TRF1 in regulating metabolism Ministerio de Ciencia, Innovación y Universidades (España) European Commission Fundación Botín (España) Fundación Humanismo y Ciencia Depto. de Medicina y Cirugía Animal Fac. de Veterinaria TRUE pub 2025-10-22T12:53:47Z 2025-10-22T12:53:47Z 2025 journal article VoR https://hdl.handle.net/20.500.14352/125250 XXXX-XXXX 10.18632/aging.206320 1945-4589 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82623-R/ES/TELOMEROS Y ENFERMEDAD/ MICIU/AEI/ 10.13039/ 501100011033 GA 882385 PRE2018-083335 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CPP2021-008483/ES/Desarrollo de una nueva terapia génica para el tratamiento de la Fibrosis Idiopática./ Ruano, J. L., Bejarano, L., Serrano, R., Diaz, R. A., Flores, J. M., López, A. C., & Blasco, M. A. (2025). Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles. Aging, 17(9), 2410–2429. https://doi.org/10.18632/aging.206320 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access application/pdf Impact Journals