2026-07-25T16:40:44Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/125302024-04-04T15:02:32Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Cárdenas Cárdenas, Nivia author Martín, Virginia author Arroyo Rodríguez, Rebeca author López, Mario author Carrera, Marta author Badiola, Carlos author Jiménez Quintana, Esther Antonia author Rodríguez Gómez, Juan Miguel author 2019-02-12 Acute otitis media (AOM) is one of the most common bacterial infections in children. Empiric antibiotherapy leads to increasing antimicrobial resistance rates among otopathogens and may impair the correct development of the microbiota in early life. In this context, probiotics seem to be an attractive approach for preventing recurrent AOM (rAOM) through the restoration of the middle ear and nasopharyngeal microbiota. The aim of this study was the selection of a probiotic strain (Lactobacillus salivarius PS7), specifically tailored for its antagonism against otopathogens. Since L. salivarius PS7 was safe and displayed a strong antimicrobial activity against otopathogens, its efficacy in preventing rAOM was assessed in a trial involving 61 children suffering from rAOM. Children consumed daily ~1 × 109 CFU of L. salivarius PS7, and the number of AOM episodes were registered and compared with that observed in the previous 6 and 12 months. The microbiota of samples collected from the external auditory canal samples was quantitatively and qualitatively assessed. The number of AOM episodes during the intervention period decreased significantly (84%) when compared to that reported during the 6 months period before the probiotic intervention. In conclusion, L. salivarius PS7 is a promising strain for the prevention of rAOM in infants and children. 2072-6643 10.3390/nu11020376 https://hdl.handle.net/20.500.14352/12530 https://doi.org/10.3390/nu11020376 https://www.mdpi.com/2072-6643/11/2/376 Prevention of Recurrent Acute Otitis Media in Children Through the Use of Lactobacillus salivarius PS7, a Target-Specific Probiotic Strain