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oai:docta.ucm.es:20.500.14352/1255192025-10-31T00:51:13Zcom_20.500.14352_14col_20.500.14352_15

Sánchez Beltrán, María Del Carmen Herráiz, Ana Ciudad Cabañas, María José Arias, Marta Alonso, Raquel Doblas, Carmen Llama Palacios, María Arantxazu Collado Yurrita, Luis Rodolfo 2025-10-30T11:35:23Z 2025-10-30T11:35:23Z 2024-07-13 Sánchez, M. C., Herráiz, A., Ciudad, M. J., Arias, M., Alonso, R., Doblas, C., Llama-Palacios, A., & Collado, L. (2024). Metabolomics and Biochemical Benefits of Multivitamin and Multimineral Supplementation in Healthy Individuals: A Pilot Study. Foods, 13(14), 2207. https://doi.org/10.3390/foods13142207 2304-8158 10.3390/foods13142207 https://hdl.handle.net/20.500.14352/125519 https:// doi.org/10.3390/foods13142207 https://www.mdpi.com/2304-8158/13/14/2207 Scientific evidence regarding the effectiveness of vitamin and mineral supplements in healthy individuals remains scarce. In a randomized, double-blind study, 30 healthy individuals were assigned to receive a single daily dose of multivitamin and multimineral supplementation or a double daily dose for 30 days. Before and after the intake, an untargeted metabolomics assay for serum metabolites was conducted by hydrophilic interaction liquid chromatography-mass spectrometry, and clinical assessments of peripheral blood samples were performed. A paired t-test for metabolic analysis, adjusted using the false discovery rate (FDR) and p-value correction method (rate of change > 2 and FDR < 0.05), the Shapiro-Wilk test, Student's t-test, and the Mann-Whitney U test were applied depending on the variable, with a 5% significance level. An impact on oxidative stress was observed, with a significant reduction in homocysteine levels and an increment of pyridoxic acid (vitamin B6). The effect on energy metabolism was shown by a significant increase in diverse metabolites, such as linoleoylcarnitine. Serum iron and calcium levels were also impacted. Overall, we observed a nutritional balance compatible with a good state of health. In conclusion, beneficial effects on adult health were demonstrated in relation to oxidative stress, energy metabolism, and nutritional balance. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Metabolomics and Biochemical Benefits of Multivitamin and Multimineral Supplementation in Healthy Individuals: A Pilot Study journal article