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00925njm 22002777a 4500 dc Valencia Mahón, Jaris author Martínez Fernández De Sevilla, Lidia author Fraile Ramos, Alberto author Sacedón Ayuso, Rosa author Jiménez Pérez, Eva author Vicente López, Ángeles author Varas Fajardo, Alberto author 2019-07-14 Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progression. In the present study, we analyse whether acute lymphoblastic leukaemia (ALL) cells can affect the differentiation of dendritic cells and macrophages and the involvement of BMP pathway in the process. We show that ALL cells produce BMP4 and that conditioned media from ALL cells promote the generation of dendritic cells with immunosuppressive features and skew M1-like macrophage polarization towards a less pro-inflammatory phenotype. Likewise, BMP4 overexpression in ALL cells potentiates their ability to induce immunosuppressive dendritic cells and favours the generation of M2-like macrophages with pro-tumoral features. These results suggest that BMP4 is in part responsible for the alterations in dendritic cell and macrophage differentiation produced by ALL cells. Valencia Mahón, J., Martínez Fernández De Sevilla, L., Fraile Ramos, A. et al. «Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4». Cells, vol. 8, n.o 7, julio de 2019, p. 722. DOI.org (Crossref), https://doi.org/10.3390/cells8070722. 2073-4409 10.3390/cells8070722 https://hdl.handle.net/20.500.14352/12563 https://doi.org/10.3390/cells8070722 https://www.mdpi.com/2073-4409/8/7/722 Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4