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00925njm 22002777a 4500 dc Salazar Roa, María author Lorente Pérez, María Del Mar author García Taboada, Elena author Gómez, Eduardo P. author Dávila, David author Zúñiga García, Patricia author Flores Landeira, Juana María author Rodríguez, Antonio author Hegedus, Zoltan author Mosen Ansorena, David author Aransay, Ana M. author Hernandez Tiedra, Sonia author López Valero, Israel author Quintanilla, Miguel author Sánchez García, María Cristina author Iovanna, Juan L author Dusetti, Nelson author Guzmán Pastor, Manuel author Francis, Sheila E. author Carracedo, Arkaitz author Kiss-Toth, Endre author Velasco Díez, Guillermo author 2015-04 In a recent article, we found that Tribbles pseudokinase 3 (TRIB3) plays a tumor suppressor role and that this effect relies on the dysregulation of the phosphorylation of v-akt murine thymoma viral oncogene homolog (AKT) by the mammalian target of rapamycin complex 2 (mTORC2 complex), and the subsequent hyperphosphorylation and inactivation of the transcription factor Forkhead box O3 (FOXO3). Salazar, M., Lorente, M., García-Taboada, E., Gómez, E. P., Dávila, D., Zúñiga-García, P., … Velasco, G. (2015). TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling. Molecular & Cellular Oncology, 2(3). https://doi.org/10.4161/23723556.2014.980134 10.4161/23723556.2014.980134 https://hdl.handle.net/20.500.14352/125762 2372-3556 http://dx.doi.org/10.4161/23723556.2014.980134 https://www.tandfonline.com/doi/10.4161/23723556.2014.980134?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling