2026-06-29T09:25:19Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/125842023-08-28T05:33:16Zcom_20.500.14352_14col_20.500.14352_15

Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study San Mauro Martín, Ismael Garicano Vilar, Elena Sanz Rojo, Sara Collado Yurrita, Luis Rodolfo Pérez Arruche, Eva Arce Delgado, Esperanza Blumenfeld Olivares, Javier Andrés children cholesterol genetics low-density lipoprotein cholesterol sterol Cardiología Microbiología médica 3205.01 Cardiología 3201.03 Microbiología Clínica Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia. Depto. de Medicina Fac. de Medicina TRUE pub 2023-06-17T12:35:50Z 2023-06-17T12:35:50Z 2019-10-21 journal article https://hdl.handle.net/20.500.14352/12584 2072-6643 10.3390/nu11102538 eng Atribución 3.0 España https://creativecommons.org/licenses/by/3.0/es/ open access application/pdf MDPI