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00925njm 22002777a 4500 dc Carracedo Añón, Julia María author Alique, Matilde author Ramírez Carracedo, Rafael author Bodega, Guillermo author Ramírez, Rafael author 2019-08-01 Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of Cardiovascular Disease (CVDs) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVDs is the production of altered Extracellular Vesicles (EVs) by senescent endothelial cells among them, Microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. However, MVs produced by damage cell conveyed epigenetic signals, mainly involving microRNAs, which induce many of the injured responses in other vascular cells leading to the development of CVDs. Many studies strongly support that the quantification and characterization of the MVs released by senescent endothelial cells may be useful diagnostic tools in patients with CVDs, as well as a future therapeutic target for these diseases. In this review, we summarize the current knowledge linking senescence-associated MVs to the development of CVDs and discuss the roles of these MVs, in particular, in diabetic-associated increases the risk of CVDs. Carracedo, J., Alique, M., Ramírez-Carracedo, R., Bodega, G., & Ramírez, R. (2019). [Rev. of Tendothelial extracellular vesicles produced by senescent cells: Pathophysiological role in the cardiovascular disease associated with all types of diabetes mellitus]. Current Vascular Pharmacology, 17(5), 447-454. https://doi.org/10.2174/1570161116666180820115726 1570-1611 10.2174/1570161116666180820115726 https://hdl.handle.net/20.500.14352/125892 1875-6212 https://doi.org/10.2174/1570161116666180820115726 https://www.eurekaselect.com/article/92490 Endothelial Extracellular Vesicles Produced by Senescent Cells: Pathophysiological Role in the Cardiovascular Disease Associated with all Types of Diabetes Mellitus