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oai:docta.ucm.es:20.500.14352/1259952025-11-13T01:11:49Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Gil Martí, Beatriz author Isidro Mézcua, Julia author Poza Rodríguez, Adriana author Asti Tello, Gerson S. author Treves, Gaia author Turiégano, Enrique author Beckwith, Esteban J. author Martín Castro, Francisco Antonio author 2024-09 In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human, impacting aggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation. Gil-Martí, B., Isidro-Mézcua, J., Poza-Rodriguez, A. et al. Socialization causes long-lasting behavioral changes. Sci Rep 14, 22302 (2024). https://doi.org/10.1038/s41598-024-73218-w 10.1038/s41598-024-73218-w https://hdl.handle.net/20.500.14352/125995 2045-2322 https://doi.org/10.1038/s41598-024-73218-w https://www.nature.com/articles/s41598-024-73218-w#article-info Socialization causes long-lasting behavioral changes