2026-06-01T01:49:28Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1260582025-11-15T01:10:52Zcom_20.500.14352_14col_20.500.14352_15
Hidden inside desert rocks: Salinity triggers an increase in exopolysaccharides from endolithic cyanobacteria with anti-inflammatory potential
Casero, María Cristina
Velázquez, David
Pereira, Adrián
Tejedor, María del Mar
García, Luis
Quesada, Antonio
Cirés, Samuel
579.6
582.232(835.16)
60
577.11
Exopolysaccharides
Anti-inflammatory
Salinity
Cyanobacteria
Desert
Elastase
Halotolerant
Microbiología (Biología)
Botánica (Biología)
Biotecnología
Bioquímica (Biología)
2414 Microbiología
2417 Biología Vegetal (Botánica)
2403 Bioquímica
2304.19 Polisacáridos
This work was funded by Comunidad de Madrid and Universidad Autónoma de Madrid via LIPEPSTREM project [grant number SI3/PJI/ 2021-00461] and by MCIN/AEI/10.13039/501100011033/ FEDER, UE, via MERIDIAN project [grant number PID2022-136691NA-I00]. M. C. Casero is the recipient of a Juan de la Cierva-Formación postdoctoral grant [FJC2020-044126-I] funded by MCIN/AEI/ 10.130 39/501100011033 and by European Union NextGenerationEU/PRTR.
Endolithic cyanobacteria thriving in rocks of deserts remain an unexplored source for the quest of novel bioproducts in extreme environments. In this work, 7 endolithic cyanobacteria from the polyextreme Atacama Desert, covering four genera and three lithic substrates, were investigated for the production of exopolysaccharides with anti-inflammatory potential. A moderate salinity (20 g NaCl L− 1 ) was tolerated by all strains, triggering a 3–9-fold increase in exopolysaccharides (EPS) yield in 4 of them that counteracted the growth decrease due to NaCl stress. EPS from all strains showed anti-elastase activity with inter-strain and inter-salinity variations. The moderate EPS productivity by Gloeocapsa sp. UAM572 (0.4 mg EPS L− 1 day− 1 ), elevated antielastase capacity of Chroococcidiopsis sp. UAM579 EPS (IC50 = 78 μg mL− 1 ) and the first biotechnological data of genus Pseudoacaryochloris, provide a promising foundation for potential applications of EPS from endolithic cyanobacteria in cosmetics and biomedicine, whose opportunities and challenges are discussed herein.
Comunidad de Madrid
Universidad Autónoma de Madrid
Ministerio de Ciencia e Innovación (España)
European Commission
Depto. de Genética, Fisiología y Microbiología
Fac. de Ciencias Biológicas
TRUE
pub
2025-11-13T09:14:52Z
2025-11-13T09:14:52Z
2024-12
journal article
VoR
https://hdl.handle.net/20.500.14352/126058
2211-9264
10.1016/j.algal.2024.103817
eng
S2021/SI3%2FPJI%2F00461/Exploración del potencial de producción de LÍPidos y ExoPoliSacáridos bioactivos en cianobacterias aisladas de ambientes exTREmos (LIPEPSTREM)
info:eu-repo/grantAgreement/MICINN/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136691NA-I00/RELEVANCIA DE LOS FACTORES AMBIENTALES Y MICROBIANOS EN LA DIVERSIDAD DE LOS ECOSISTEMAS TERRESTRES ANTÁRTICOS
Casero, M. C., Velázquez, D., Pereira, A., Tejedor, M. d. M., García, L., Quesada, A., & Cirés, S. (2024). Hidden inside desert rocks: Salinity triggers an increase in exopolysaccharides from endolithic cyanobacteria with anti-inflammatory potential. Algal Research, 84. https://doi.org/10.1016/J.ALGAL.2024.103817
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
open access
application/pdf
Elsevier