2026-06-28T15:21:08Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1263212025-11-22T01:06:11Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Iglesias Velázquez, Óscar author Gf Tresguerres, F. author Fernández-Tresguerres Hernández-Gil, Isabel author Leco Berrocal, María Isabel author López-Pintor Muñoz, Rosa María author Baca, L. author Torres García Denche, Jesús 2025-11-21T10:16:35Z 2025-11-21T10:16:35Z 2024-03-14 Iglesias-Velazquez O, Gf Tresguerres F, F Tresguerres I, Leco-Berrocal I, Lopez-Pintor R, Baca L, Torres J. OsteoMac: A new player on the bone biology scene. Ann Anat. 2024 Jun;254:152244. doi: 10.1016/j.aanat.2024.152244 0940-9602 10.1016/j.aanat.2024.152244 https://hdl.handle.net/20.500.14352/126321 1618-0402 https://doi.org/10.1016/j.aanat.2024.152244 38492654 https://www.sciencedirect.com/science/article/pii/S0940960224000360?via%3Dihubhttps://pubmed.ncbi.nlm.nih.gov/38492654/ The knowledge of bone biology has undergone major advances in recent decades. In bone, resorbing osteoclasts have classically been described as tissue-resident macrophages, however, it is currently known that a new subtype of macrophages, called OsteoMacs, are specialised bone-resident macrophages, which, depending on certain conditions, may play an important role not only in bone homeostasis, but also in promoting pro-anabolic functions or in creating an inflammatory environment. There is growing evidence that these osteal macrophages may influence the development of bone-loss diseases. It is essential to understand the biological bases underlying bone physiological processes to search for new therapeutic targets for bone-loss diseases, such as osteoporosis, rheumatoid arthritis, or even periodontal disease. This narrative review provides an update on the origin, characterisation, and possible roles of osteoMacs in bone biology. Finally, the potential clinical applications of this new cell in bone-loss disorders are discussed. eng Attribution-NonCommercial 4.0 International Osteomac. A new player on the bone biology scene journal article 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URL https://docta.ucm.es/bitstreams/6d404416-ce21-49a9-adc1-c865c57f010c/download File MD5 928ec93c9c92beff85e02190c970e64f 1846094 application/pdf Ann Anat. 2024 Jun;254:152244.pdf