2026-06-27T15:23:34Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/126562023-08-25T11:09:59Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Vargas-Mendoza, Nancy
author
Vázquez Velasco, Miguel
author
González Torres, Laura
author
Benedí González, Juana María
author
Sánchez Muniz, Francisco José
author
Morales-González, Jose
author
Jaramillo-Morales, Osmar
author
Valadez-Vega, Carmen
author
Bautista, Mirandeli
2023-06-17T12:37:45Z
2023-06-17T12:37:45Z
2018-11-30
2076-3921
10.3390/antiox7120178
https://hdl.handle.net/20.500.14352/12656
https://doi.org/10.3390/antiox7120178
https://www.mdpi.com/2076-3921/7/12/178
Geranium schiedeanum has been used in traditional therapies as an antiseptic, antipyretic, and as analgesic. The present study was designed to evaluate the pretreatment with G. schiedeanum total extract (GS) and its active metabolites on stimulating the endogenous antioxidant defense system (EADS): catalase (Cat), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione reduction index (RI GSH/GSSG) in rat liver treated with a sublethal dose (6.6 mmol/Kg) of thioacetamide (TAA) in order to probe the capacity of GS and the active compounds to reduce liver injury. This was assessed by measuring aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (BILT) in rats pretreated or not with TAA, and pretreated or not with GS and its metabolites. The results showed that GS was able to induce the production of EADS enzymes, increasing redox index GSH/GSSG at 24 and 48 h after intoxication, and both the extract and the ellagic acid exhibited a significant reduction of hepatic damage markers. Our data confirmed the hepatoprotective effect of GS and its metabolites, like ellagic acid, support the possible use of this extract in the treatment of liver injury.
eng
Atribución 3.0 España
Effect of Extract and Ellagic Acid from Geranium schiedeanum on the Antioxidant Defense System in An Induced-Necrosis Model
journal article
URL
https://docta.ucm.es/bitstreams/4e6924e1-d39a-4390-aa8c-4bea08add780/download
File
MD5
cb95dcc99ca7163c75c95837025a4eba
1729103
application/pdf
antioxidants-07-00178.pdf