2026-06-28T20:29:55Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/127172023-08-26T16:40:04Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Arumugam, Natarajan author Almansour, Abdulrahman I. author Suresh Kumar, Raju author Govindasami, Periyasami author Al-thamili, Dhaifallah author Krishnamoorthy, Rajapandian author Periasamy, Vaiyapuri Subbarayan author Alshatwi, Ali author Mahalingam, S. M. author Thangamani, Shankar author Menéndez Ramos, José Carlos author 2018-05-05 A series of spirooxindolopyrrolidine fused N -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds 5i and 5m exhibited a better cytotoxicity than the anticancer drug bleomycin. In ddition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds 5a–m led to their apoptotic cell death. 1420-3049 10.3390/molecules23051094 https://hdl.handle.net/20.500.14352/12717 https://doi.org/10.3390/molecules23051094 https://www.mdpi.com/1420-3049/23/5/1094 Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines