2026-06-29T09:30:10Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/127172023-08-26T16:40:04Zcom_20.500.14352_14col_20.500.14352_15
Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
Arumugam, Natarajan
Almansour, Abdulrahman I.
Suresh Kumar, Raju
Govindasami, Periyasami
Al-thamili, Dhaifallah
Krishnamoorthy, Rajapandian
Periasamy, Vaiyapuri Subbarayan
Alshatwi, Ali
Mahalingam, S. M.
Thangamani, Shankar
Menéndez Ramos, José Carlos
547
domino reaction
1
3-dipolar cycloaddition
ionic liquids
cytotoxicity assays
molecular docking
Química orgánica (Farmacia)
A series of spirooxindolopyrrolidine fused N -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds 5i and 5m exhibited a better cytotoxicity than the anticancer drug bleomycin. In ddition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds 5a–m led to their apoptotic cell death.
Deanship of Scientific Research at King Saud University
Depto. de Química en Ciencias Farmacéuticas
Fac. de Farmacia
TRUE
pub
2023-06-17T12:39:27Z
2023-06-17T12:39:27Z
2018-05-05
journal article
https://hdl.handle.net/20.500.14352/12717
1420-3049
10.3390/molecules23051094
eng
RGP-026
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
open access
application/pdf
MDPI