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oai:docta.ucm.es:20.500.14352/1282662025-12-03T00:57:48Zcom_20.500.14352_14col_20.500.14352_15

Timing the juvenile-adult neurohormonal transition: functions and evolution Barredo, Celia G. Gil-Marti, Beatriz Deveci, Derya Romero, Nuria M. Martín Castro, Francisco Antonio Puberty and metamorphosis are two major developmental transitions linked to the reproductive maturation. In mammals and vertebrates, the central brain acts as a gatekeeper, timing the developmental transition through the activation of a neuroendocrine circuitry. In addition to reproduction, these neuroendocrine axes and the sustaining genetic network play additional roles in metabolism, sleep and behavior. Although neurohormonal axes regulating juvenile-adult transition have been classically considered the result of convergent evolution (i.e., analogous) between mammals and insects, recent findings challenge this idea, suggesting that at least some neuroendocrine circuits might be present in the common bilaterian ancestor Urbilateria. The initial signaling pathways that trigger the transition in different species appear to be of a single evolutionary origin and, consequently, many of the resulting functions are conserved with a few other molecular players being co-opted during evolution. 2025-12-02T08:58:05Z 2025-12-02T08:58:05Z 2025-12-02T08:58:05Z 2021-02 review article https://hdl.handle.net/20.500.14352/128266 1664-2392 10.3389/fendo.2020.602285 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-094630-B-I00/ES/FUNCIONES DEL EJE NEURO-HORMONAL PTTH%2FTORSO DE DROSOPHILA EN LA FISIOLOGIA ADULTA/ Barredo CG, Gil-Marti B, Deveci D, Romero NM and Martin FA (2021) Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution. Front. Endocrinol. 11:602285. doi: 10.3389/fendo.2020.602285 http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Frontiers