2026-06-28T20:38:55Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1289162025-12-16T01:10:04Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Klionsky, Daniel J. author Bravo San Pedro, José Manuel author Pietrocola, Federico author 2021 Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, et al. Autophagy in major human diseases. EMBO journal. 2021;40(19):e108863 0261-4189 10.15252/embj.2021108863 https://hdl.handle.net/20.500.14352/128916 1460-2075 https://doi.org/10.15252/embj.2021108863 34459017 https://link.springer.com/article/10.15252/embj.2021108863 https://pubmed.ncbi.nlm.nih.gov/34459017/ Autophagy in major human diseases