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Ruiz Serrano, Miriam López-Alvarado Gutiérrez, María Pilar Menéndez Ramos, José Carlos 2025-12-15T12:24:39Z 2025-12-15T12:24:39Z 2010 Ruiz M, López-Alvarado P, Menéndez JC. Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process. Org Biomol Chem. 2010 Oct 21;8(20):4521-3. doi: 10.1039/c0ob00382d. Epub 2010 Aug 18. PMID: 20717611. 1477-0520 10.1039/c0ob00382d https://hdl.handle.net/20.500.14352/128965 1477-0539 https://doi.org/10.1039/C0OB00382D https://pubs.rsc.org/en/content/articlelanding/2010/ob/c0ob00382d#!divAbstract https://pubs.rsc.org/en/content/articlepdf/2010/ob/c0ob00382d An efficient synthesis of the N-methylwelwistatin tetracyclic core in only two steps from Kornfeld's ketone is described, whose key transformation involves the generation of a fused bicyclo[4.3.1]decane ring system through a one-pot sequence comprising a Michael-intramolecular aldolization anionic domino process and a DBU-promoted hydrolysis of the N-pivaloyl protecting group. Besides providing the most efficient synthesis of the welwistatin core to date, this method has the advantage of installing an oxygenated function at the welwistatin D ring. eng http://creativecommons.org/licenses/by/4.0/ open access Attribution 4.0 International Concise and very efficient synthesis of the N-methylwelwistatin tetracyclic core based on an anionic domino process journal article