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Mild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides Sridharan, Vellaisamy Menéndez Ramos, José Carlos Ruiz Serrano, Miriam 547 Acetoacetylation Chiral auxiliaries Dicarbonyl compounds Esters Amides Química orgánica (Química) 2306 Química Orgánica In the presence of sodium acetate, the reaction between 2,2,6-trimethyl-4H-1,3-dioxin-4-one and secondary or tertiary alcohols (including chiral ones) or primary or secondary amines could be carried out in refluxing tetrahydrofuran, under much milder conditions than those described in the literature. In these new conditions, side products normally observed using the traditional protocol were avoided, and b-keto esters and b-ketoamides were normally obtained in quantitative yields Ministerio de Ciencia, Innovación y Universidades (España) Universidad Complutense de Madrid Comunidad de Madrid Depto. de Química en Ciencias Farmacéuticas Fac. de Farmacia TRUE pub 2025-12-15T14:11:02Z 2025-12-15T14:11:02Z 2009 journal article AM https://hdl.handle.net/20.500.14352/129002 0039-7881 10.1055/s-0029-1217135 1437-210X eng info:eu-repo/grantAgreement/MEC//CTQ2006-10930/ES/NUEVAS REACCIONES MULTICOMPONENTE CATALIZADAS POR ESPECIES DE CERIO (IV): APLICACIONES EN LA GENERACION DE DIVERSIDAD Y COMPLEJIDAD MOLECULAR/ info:eu-repo/grantAgreement/UCM-CAM//920234 Sridharan V, Ruiz M, Menéndez J. Mild and High-Yielding Synthesis of β-Keto Esters and β-Ketoamides. Synthesis 2010;2010:1053–7. https://doi.org/10.1055/s-0029-1217135. Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf application/pdf Thieme Gruppe