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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles Galluzzi, Lorenzo Levine, Beth Green, Douglas R. Kroemer, Guido 615.01/.03 Autophagy Pharmacological modulation Therapeutic potential Drug discovery Ciencias Biomédicas Farmacología (Medicina) 32 Ciencias Médicas 3209 Farmacología Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic. Depto. de Fisiología Fac. de Medicina TRUE pub 2025-12-16T08:41:51Z 2025-12-16T08:41:51Z 2017-05 journal article VoR https://hdl.handle.net/20.500.14352/129054 1474-1776 10.1038/nrd.2017.22 1474-1784 eng Galluzzi L, Bravo-San Pedro JM, Levine B, Green DR, Kroemer G. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 2017 Jul;16(7):487–511. restricted access application/pdf Springer Nature