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oai:docta.ucm.es:20.500.14352/1291342025-12-17T00:56:15Zcom_20.500.14352_14col_20.500.14352_15

Bidirectional modulation of synaptic transmission by insulin-like growth factor-I Noriega-Prieto, José A. Maglio,Laura E. Perez-Domper, Paloma Dávila, Juan Carlos Gutíerrez, Antonia Torres-Alemán, Ignancio Fernandez de Sevilla, David 615 Insulin-like growth factor-I LTD Spike-timing dependent plasticity Hebbian plasticity Hebbian plasticity Medicina 3209.09 Psicofarmacología Abstract Insulin-like growth factor-I (IGF-I) plays a key role in the modulation of synaptic plasticity and is an essential factor in learning and memory processes. However, during aging, IGF-I levels are decreased, and the effect of this decrease in the induction of synaptic plasticity remains unknown. Here we show that the induction of N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) at layer 2/3 pyramidal neurons (PNs) of the mouse barrel cortex is favored or prevented by IGF-I (10 nM) or IGF-I (7 nM), respectively, when IGF-I is applied 1 h before the induction of Hebbian LTP. Analyzing the cellular basis of this bidirectional control of synaptic plasticity, we observed that while 10 nM IGF-I generates LTP (LTPIGF-I) of the post-synaptic potentials (PSPs) by inducing long-term depression (LTD) of the inhibitory post-synaptic currents (IPSCs), 7 nM IGF-I generates LTD of the PSPs (LTDIGF-I) by inducing LTD of the excitatory post-synaptic currents (EPSCs). This bidirectional effect of IGF-I is supported by the observation of IGF-IR immunoreactivity at both excitatory and inhibitory synapses. Therefore, IGF-I controls the induction of Hebbian NMDAR-dependent plasticity depending on its concentration, revealing novel cellular mechanisms of IGF-I on synaptic plasticity and in the learning and memory machinery of the brain. Depto. de Fisiología Fac. de Medicina TRUE pub 2025-12-16T12:30:36Z 2025-12-16T12:30:36Z 2024-06-07 journal article VoR https://hdl.handle.net/20.500.14352/129134 XXXX-XXXX 10.3389/fncel.2024.1390663 eng Noriega-Prieto, José Antonio, et al. «Bidirectional modulation of synaptic transmission by insulin-like growth factor-I». Frontiers in Cellular Neuroscience, vol. 18, junio de 2024, p. 1390663. https://doi.org/10.3389/fncel.2024.1390663. Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ open access application/pdf Frontiers