2026-06-26T16:25:33Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/129352024-04-16T18:36:51Zcom_20.500.14352_14col_20.500.14352_15

Colilla Nieto, Montserrat Izquierdo Barba, Isabel Vallet Regí, María Dulce Nombre 2023-06-17T13:18:19Z 2023-06-17T13:18:19Z 2018-11-22 2305-6320 10.3390/medicines5040125 https://hdl.handle.net/20.500.14352/12935 https://doi.org/10.3390/medicines5040125 http://www.ucm.es/valletregigroup https://www.mdpi.com/2305-6320/5/4/125 Zwitterionization of biomaterials has been heightened to a potent tool to develop biocompatible materials able to inhibit bacterial and non-specific proteins adhesion. This constitutes a major progress in the biomedical field. This manuscript overviews the main functionalization strategies that have been reported up to date to design and develop these advanced biomaterials. On this regard, the recent research efforts dedicated to provide their surface of zwitterionic nature are summarized by classifying biomaterials in two main groups. First, we centre on biomaterials in clinical use, concretely bioceramics and metallic implants. Finally, we revise emerging nanostructured biomaterials, which are receiving growing attention due to their multifunctionality and versatility mainly in the local drug delivery and bone tissue regeneration scenarios. eng https://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España The role of zwitterionic materials in the fight against proteins and bacteria journal article