2026-06-29T02:13:32Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1294152025-12-20T01:09:46Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Román González, Elvira author Correia, Ines author Prieto Prieto, Antonio Daniel author Alonso Monge, Rebeca María Del Mar author Pla Alonso, Jesús 2025-12-19T10:07:30Z 2025-12-19T10:07:30Z 2019 Román E, Correia I, Prieto D, et al. The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway. Int Microbiol 2020;23:23–9. https://doi.org/10.1007/s10123-019-00069-1 10.1007/s10123-019-00069-1 https://hdl.handle.net/20.500.14352/129415 https://doi.org/10.1007/s10123-019-00069-1 In 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide range of stress conditions frequently encountered by fungi in their common habitats. MAPK signaling is initiated at the plasma membrane, where triggering stimuli lead to a phosphorylation cascade that ultimately activates transcription factors to ensure an appropriate adaptive response. In pathogenic fungi, the HOG pathway gains special significance as it is involved in traits related to pathogenicity; these include biofilm formation, adhesion to surfaces, and morphogenetic and epigenetic transitions. It also plays a role in controlling both the pathogen and the commensal state program. Understanding the signals leading to its activation, the elements of the pathways and the targets of the pathway are therefore of primary importance in the design of novel antifungals. eng Attribution-NonCommercial-NoDerivatives 4.0 International The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway review article 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URL https://docta.ucm.es/bitstreams/753950f4-a1b4-4c43-ad6d-778844839bdb/download File MD5 816573fcfe45e80499dc4adce7020972 446973 application/pdf The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway_final.pdf