2026-06-27T23:50:01Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/129482024-09-04T12:39:50Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense
author
Villaverde Cantizano, Gonzalo
author
Alfranca, Arantzazú
author
González-Murillo, África
author
Melen, Gustavo J.
author
Castillo, Rafael R.
author
Ramírez, Manuel
author
Baeza, Alejandro
author
Vallet Regí, María Dulce Nombre
2023-06-17T13:18:25Z
2023-06-17T13:18:25Z
2018-12-10
Villaverde Cantizano, G., Alfranca, A., González Murillo, Á. et al. «Molecular Scaffolds as Double‐Targeting Agents For the Diagnosis and Treatment of Neuroblastoma». Angewandte Chemie International Edition, vol. 58, n.o 10, marzo de 2019, pp. 3067-72. DOI.org (Crossref), https://doi.org/10.1002/anie.201811691.
1433-7851
10.1002/anie.201811691
https://hdl.handle.net/20.500.14352/12948
https//doi.org/10.1002/anie.201811691
https://www.wiley.com/WileyCDA/Brand/id-29.html?category=For+Workinghttp://www.ucm.es/valletregigroup
The selective delivery of therapeutic and imaging agents to tumoral cells has been postulated as some of the most important challenges in nanomedicine field. The cellular selectivity of nanocarriers is usually achieved by their surface decoration with targeting moieties able to recognize these cells in a specific manner. Neuroblastoma (NB) is the most frequent extra-cranial pedriatic tumor, almost incurable at advanced stages. Meta-iodo-benzilguanidine (MIBG) is widely used for the diagnosis of this disease due to its strong affinity by the norepinephrine transporter (NET) usually overexpressed on the membrane of the malignant cells. Herein, a complete family of novel Y-shaped scaffolds which contains structural MIBG analogues covalently attached in each end of the Y-structure has been synthesized. The enhanced cellular uptake capacities of these double-targeting ligands have been evaluated in vitro and in vivo yielding one specific Y-shape structure which presents capacity to be engulfed by the malignant cells and be accumulated in the tumoral tissue, significantly higher than the structure which contains only one single targeting agent. This Y-shaped ligand can provide a powerful tool for the current and treatment diagnosis of this disease.
eng
Molecular scaffolds as double targeting agents for the diagnosis and treatment of Neuroblastoma.
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201811691_R2.pdf
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201811691_R2.pdf.txt