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Muñoz Yagüe, María Teresa Marín Gabriel, José Carlos Colina Ruiz-Delgado, Francisco Ibarrola De Andrés, Carolina Natalia López Alonso, G. Martín, M. A. Solís Herruzo, José Antonio 2026-01-22T07:25:03Z 2026-01-22T07:25:03Z 2006 Muñoz-Yagüe MT, Marín JC, Colina F, Ibarrola C, López-Alonso G, Martín MA, Solís-Herruzo JA. Chronic primary intestinal pseudo-obstruction from visceral myopathy. Rev Esp Enferm Dig. 2006 Apr;98(4):292-302. English, Spanish. doi: 10.4321/s1130-01082006000400007 1130-0108 10.4321/s1130-01082006000400007 https://hdl.handle.net/20.500.14352/130767 https://doi.org/10.4321/s1130-01082006000400007 16792457 https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082006000400007 https://pubmed.ncbi.nlm.nih.gov/16792457/ Chronic intestinal pseudo-obstruction is an uncommon syndrome characterized by relapsing episodes suggesting intestinal obstruction during which no mechanical causes are identified to account for symptoms. Etiologic factors may be manifold. Among them a number of neurologic conditions, gastrointestinal smooth muscle myopathies, endocrino-metabolic and autoimmune diseases, and the use of selected drugs stand out. We report a case of chronic intestinal pseudo-obstruction originating in a sporadic, primary intestinal myopathy that corresponds to no type thus far described. A histological study of the intestinal wall showed disrupted muscle bundles and the presence of interstitial edema. Myocytes had severe degenerative changes, and no alterations were seen in submucosal and myenteric plexus neurons. The activity of enzyme complexes in the mitochondrial respiratory chain, and of thymidine phosphorylase was normal. No mitochondrial DNA changes were seen. eng restricted access Chronic primary intestinal pseudo-obstruction from visceral myopathy journal article