2026-06-28T20:22:34Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1307742026-01-23T01:29:35Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author López Medrano, Francisco author Fernández Ruiz, Mario author Origüen Sabater, Julia author Escudero Portugués, Rosa María author Candel González, Francisco Javier author Pérez Flores, Isabel María author Andrés Belmonte, Amado author Aguado García, José María 2026-01-22T09:03:53Z 2026-01-22T09:03:53Z 2020-02-01 López-Medrano F, Silva JT, Fernández-Ruiz M, Vidal E, Origüen J, Calvo-Cano A, Luna-Huerta E, Merino E, Hernández D, Jironda-Gallegos C, Escudero R, Gioia F, Moreno A, Roca C, Cordero E, Janeiro D, Sánchez-Sobrino B, Montero MM, Redondo D, Candel FJ, Pérez-Flores I, Armiñanzas C, González-Rico C, Fariñas MC, Rodrigo E, Loeches B, López-Oliva MO, Montejo M, Lauzurica R, Horcajada JP, Pascual J, Andrés A, Aguado JM; REIPI, REDinREN, GESITRA-IC/SEIMC. Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients: results of a Spanish multicenter cohort. Am J Transplant. 2020;20(2):451-62. doi:10.1111/ajt.15614. 1600-6135 10.1111/ajt.15614 https://hdl.handle.net/20.500.14352/130774 1600-6143 https://doi.org/10.1111/ajt.15614 31550408 https://www.amjtransplant.org/article/S1600-6135(22)22198-4/fulltexthttps://www.sciencedirect.com/science/article/pii/S1600613522221984https://pubmed.ncbi.nlm.nih.gov/31550408/ Oral fosfomycin may constitute an alternative for the treatment of lower urinary tract infections (UTIs) in kidney transplant recipients (KTRs), particularly in view of recent safety concerns with fluroquinolones. Specific data on the efficacy and safety of fosfomycin in KTR are scarce. We performed a retrospective study in 14 Spanish hospitals including KTRs treated with oral fosfomycin (calcium and trometamol salts) for posttransplant cystitis between January 2005 and December 2017. A total of 133 KTRs developed 143 episodes of cystitis. Most episodes (131 [91.6%]) were produced by gram-negative bacilli (GNB), and 78 (54.5%) were categorized as multidrug resistant (including extended-spectrum β-lactamase-producing Enterobacteriaceae [14%] or carbapenem-resistant GNB [3.5%]). A median daily dose of 1.5 g of fosfomycin (interquartile range [IQR]: 1.5-2) was administered for a median of 7 days (IQR: 3-10). Clinical cure (remission of UTI-attributable symptoms at the end of therapy) was achieved in 83.9% (120/143) episodes. Among those episodes with follow-up urine culture, microbiological cure at month 1 was achieved in 70.2% (59/84) episodes. Percutaneous nephrostomy was associated with a lower probability of clinical cure (adjusted odds ratio: 10.50; 95% confidence interval: 0.98-112.29; P = 0.052). In conclusion, fosfomycin is an effective orally available alternative for treating cystitis among KTRs. eng Attribution-NonCommercial-NoDerivatives 4.0 International Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients—Results of a Spanish multicenter cohort journal article 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URL https://docta.ucm.es/bitstreams/33304dbe-de81-4eb5-a7d0-091b3849d45c/download File MD5 3e5032adba78e80c67a2097b9e24a383 408498 application/pdf AJT 2020 - Fosfomicina ITU SOT tx renal - Q1 - primer autor.pdf