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oai:docta.ucm.es:20.500.14352/1307882026-01-23T01:12:38Zcom_20.500.14352_14col_20.500.14352_15

A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hipomenes study Tiago Silva, José Pérez-Jacoiste Asín, María Asunción Fernández Ruiz, Mario González Monte, Esther Andrés Belmonte, Amado Aguado García, José María López Medrano, Francisco Antimicrobial prescription Antimicrobial stewardship Hospital-acquired infection Kidney transplantation Multidrug-resistant bacteria. Ciencias Biomédicas 32 Ciencias Médicas Financiado con Fondos FEDER Infection is a common complication in kidney transplant recipients (KTRs). The usefulness of antimicrobial stewardship programs (ASP) and hospital-acquired infection control (HAIC) initiatives in the general inpatient population is well established. We performed a quasi-experimental study to evaluate a joint ASP/HAIC initiative focused on KTRs. A dedicated ASP team optimized antimicrobial prescriptions in consecutive KTRs during the intervention period (June 2015-March 2016). A multifaceted, evidence-based HAIC program was concurrently implemented. Results were compared with the preceding period (June 2014-March 2015). We included 96 and 100 KTRs in the intervention and preintervention periods, respectively. There was a reduction in the consumption of meropenem (rate ratio [RR]: 0.63; 95% confidence interval [CI]: 0.53-0.75; P <.0001), ceftazidime (RR: 0.31; 95% CI: 0.21-0.45; P <.0001), vancomycin (RR: 0.65; 95% CI: 0.53-0.8; P <.0001), and ciprofloxacin (RR: 0.66; 95% CI: 0.55-0.81; P <.0001) and an increase of fosfomycin (RR: 1.80; 95% CI: 1.17-2.76; P =.008) during the intervention period. The incidence of cystitis (RR: 0.30; 95% CI: 0.28-0.33; P <.001) and upper urinary tract infection (RR: 0.56; 95% CI: 0.33-0.95; P =.04) decreased. A specific ASP/HAIC initiative was effective in optimizing antimicrobial use and reducing the incidence of common bacterial infections among KTRs. European Commission Instituto de Salud Carlos III (España) Depto. de Medicina Fac. de Medicina TRUE pub 2026-01-22T10:12:02Z 2026-01-22T10:12:02Z 2023-12-01 journal article VoR https://hdl.handle.net/20.500.14352/130788 1600-6135 10.1016/j.ajt.2023.07.009 1600-6143 eng PIE13/00045 PI19/01300 Silva JT, Montoro J, Pérez-Jacoiste Asín MA, Fernández-Ruiz M, Polanco N, González E, et al. A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: the Hipomenes study. Am J Transplant. 2023;23(12):1949-1960. doi:10.1016/j.ajt.2023.07.009. Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Elsevier