2026-06-08T12:56:06Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1312962026-01-31T01:20:21Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Matamoros Felipe, José Antonio author García Martín, Elena Salobrar author Salazar Corral, Juan José author López Cuenca, Inés author Hurtado, Lorena Elvira author Martínez López, Miguel Ángel author Rubio Casado, Sara author Paleo García, Víctor author Hoz Montañana, María Rosa De author Ramírez Sebastián, José Manuel author Villa, Pedro de la author Fernández Albarral, José author Ramírez Sebastián, Ana Isabel 2026-01-30T18:19:19Z 2026-01-30T18:19:19Z 2026-01-20 Matamoros, J.A.; Salobrar-García, E.; Salazar, J.J.; López-Cuenca, I.; Elvira-Hurtado, L.; Martínez, M.A.; Rubio-Casado, S.; Paleo-García, V.; Hoz, R.d.; Ramírez, J.M.; et al. In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension. Int. J. Mol. Sci. 2026, 27, 1012. https://doi.org/10.3390/ijms27021012 1422-0067 https://doi.org/10.3390/ijms27021012 https://hdl.handle.net/20.500.14352/131296 https://doi.org/10.3390/ijms27021012 This study evaluated the early structural and functional effects of combined citicoline and coenzyme Q10 (CoQ10) (CitiQ10) treatment in a laser-induced ocular hypertension (OHT) model in Swiss albino mice, focusing on retinal inflammation and neuroprotection. Sixty male CD-1 mice were assigned to four groups: vehicle, CitiQ10, OHT, and OHT + CitiQ10. OHT was induced by laser photocoagulation of limbal and episcleral veins, and CitiQ10 was administered orally starting 15 days before induction. Intraocular pressure (IOP) was measured by rebound tonometry, retinal structure was assessed by spectral domain optical coherence tomography (SD-OCT), and function was evaluated using full-field electroretinography (ffERG). At 3 days post-induction, OHT eyes exhibited significant retinal nerve fiber layer (RNFL) thickening, increased vitreous particles, and early functional impairment, particularly reduced scotopic b-wave and oscillatory potentials. CitiQ10 treatment mitigated these changes, reducing vitreous particles, moderating RNFL alterations, and not exhibiting significant changes in ERG amplitudes. At 7 days post-induction, structural and functional deficits persisted but were less pronounced in treated eyes. These findings suggest that CitiQ10 treatment may attenuate early retinal damage in glaucoma, with OCT and ffERG serving as reliable monitoring tools, supporting the therapeutic potential of this approach in early stage disease. eng Attribution 4.0 International In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension journal article 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URL https://docta.ucm.es/bitstreams/b887b43f-2077-454b-bbd8-e03237294ccc/download File MD5 8e1f063bf6556d61bd1f14d502d17552 9654108 application/pdf ijms-27-01012.pdf