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Lozano, Blanca Teresa, Javier Fernández López, Israel Tortosa, Mariola 2026-02-05T08:11:20Z 2026-02-05T08:11:20Z 2025-10-31 Lozano, Blanca, et al. «Cyclopropylmethyl Boronic Esters as General Reagents in Transition-Metal Catalyzed Homoallylation Reactions». Journal of the American Chemical Society, vol. 147, n.o 45, noviembre de 2025, pp. 41221-28. DOI.org (Crossref), https://doi.org/10.1021/jacs.5c15781. 10.1021/jacs.5c15781 https://hdl.handle.net/20.500.14352/131542 https://doi.org/10.1021/jacs.5c15781 https://pubs.acs.org/doi/10.1021/jacs.5c15781 Herein we disclose the use of cyclopropylmethyl boronates as general reagents in Negishi-type homoallylation reactions. This strategy provides a novel approach to generate enantioenriched homoallyl-Zn species through boron-to-zinc transmetalation. Subsequent sp2–sp3 cross-coupling offers a platform for the preparation of arenes, ketones, and 1,5-dienes containing a chiral homoallylic scaffold. The method has been applied to the late-stage functionalization of known drugs and the preparation of precursors of biologically relevant compounds. Mechanistic experiments and DFT calculations provide insight into the transmetalation/ring-opening sequence. eng http://creativecommons.org/licenses/by-nc-nd/4.0/ open access Attribution-NonCommercial-NoDerivatives 4.0 International Cyclopropylmethyl Boronic Esters as General Reagents in Transition-Metal Catalyzed Homoallylation Reactions journal article