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oai:docta.ucm.es:20.500.14352/1318332026-02-07T01:06:44Zcom_20.500.14352_14col_20.500.14352_15

Díaz Tocados, Juan M. Peralta Ramírez, Alan Rodríguez Ortiz, María E. Raya, Ana I. López, Ignacio Pineda, Carmen Herencia, Carmen Montes de Oca, Addy Vergara, Noemí Steppan, Sonja Pendón Ruiz de Mier, M. Victoria Buendía, Paula Carmona, Andrés Carracedo Añón, Julia María Alcalá Díaz, Juan F. Frazao, Joao Martínez Moreno, Julio M. Canalejo, Antonio Felsenfeld, Arnold Rodríguez, Mariano Aguilera Tejero, Escolástico Almadén, Yolanda Muñoz Castañeda, Juan R. 2026-02-06T13:43:06Z 2026-02-06T13:43:06Z 2017-07 Diaz-Tocados JM, Peralta-Ramirez A, Rodríguez-Ortiz ME, Raya AI, Lopez I, Pineda C, Herencia C, Montes De Oca A, Vergara N, Steppan S, Pendon-Ruiz De Mier MV, Buendía P, Carmona A, Carracedo J, Alcalá-Díaz JF, Frazao J, Martínez-Moreno JM, Canalejo A, Felsenfeld A, Rodriguez M, Aguilera-Tejero E, Almadén Y, Muñoz-Castañeda JR. Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats. Kidney International 2017;92:1084–99. https://doi.org/10.1016/j.kint.2017.04.011. 0085-2538 10.1016/j.kint.2017.04.011 https://hdl.handle.net/20.500.14352/131833 1523-1755 https://doi.org/10.1016/j.kint.2017.04.011 https://www.sciencedirect.com/science/article/pii/S0085253817302983?via%3Dihub Although magnesium has been shown to prevent vascular calcification in vitro, controlled in vivo studies in uremic animal models are limited. To determine whether dietary magnesium supplementation protects against the development of vascular calcification, 5/6 nephrectomized Wistar rats were fed diets with different magnesium content increasing from 0.1 to 1.1%. In one study we analyzed bone specimens from rats fed 0.1%, 0.3%, and 0.6% magnesium diets, and in another study we evaluated the effect of intraperitoneal magnesium on vascular calcification in 5/6 nephrectomized rats. The effects of magnesium on established vascular calcification were also evaluated in uremic rats fed on diets with either normal (0.1%) or moderately increased magnesium (0.6%) content. The increase in dietary magnesium resulted in a marked reduction in vascular calcification, together with improved mineral metabolism and renal function. Moderately elevated dietary magnesium (0.3%), but not high dietary magnesium (0.6%), improved bone homeostasis as compared to basal dietary magnesium (0.1%). Results of our study also suggested that the protective effect of magnesium on vascular calcification was not limited to its action as an intestinal phosphate binder since magnesium administered intraperitoneally also decreased vascular calcification. Oral magnesium supplementation also reduced blood pressure in uremic rats, and in vitro medium magnesium decreased BMP-2 and p65–NF-κB in TNF-α–treated human umbilical vein endothelial cells. Finally, in uremic rats with established vascular calcification, increasing dietary magnesium from 0.1% magnesium to 0.6% reduced the mortality rate from 52% to 28%, which was associated with reduced vascular calcification. Thus, increasing dietary magnesium reduced both vascular calcification and mortality in uremic rats. eng restricted access Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats journal article