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oai:docta.ucm.es:20.500.14352/1318422026-02-07T01:01:20Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Fernández de las Peñas, Cesar author Cigarán Méndez, Margarita author Ambite Quesada, Silvia author Gómez Calero, Cristina author Fernández Palacios, Francisco Ginés author Pacho Hernández, Juan C author Tejera Alonso, Angela author Plaza Manzano, Gustavo author Valera Calero, Juan Antonio author Alvarez Mariño, Beatriz author Ordás Bandera, Carlos author Arendt Nielsen, Lars author de la Llave Rincón, Ana I author 2025-07-28 Introduction Migraine is a primary headache showing a multifactorial component that includes altered pain processing, psychological/emotional problems, neurocognitive and executive function deficits, all with a possible genetic association. The aim of the current study will be to evaluate the association between sensitisation, psychological/emotional, neurocognitive and genetic profile on conditioned pain modulation (CPM) in women with migraine from a multidisciplinary perspective. Methods and analysis A cross-sectional observational case-control study including 90 women with chronic migraine, 90 women with episodic migraine and 90 women without migraine (as controls) will be conducted. Clinical variables (disability, pain), processing (sensitisation-associated, neuropathic-like symptoms), psychological/emotional (anxiety, depression, sleep quality, catastrophising), neurocognitive (attention), executive functions (memory, mental inhibition, speed processing) and genetics (Val158Met polymorphism rs4680 gene) will be assessed in all subjects by healthcare professionals. Subsequently, CPM will be evaluated with the cold-pressor test paradigm by assessing changes obtained in mechanical and thermal stimuli. The association of each group of variables on CPM will be analysed with multivariate analyses (OMNIBUS analysis of variance). A network model will also be created to identify those variables showing the greatest key measure of centrality with the rest of the severity indicators (strength, intermediation and closeness) to establish the potentially therapeutic targets in patients with migraine from a multidisciplinary point of view. Ethics and dissemination The protocol of the current study has been approved by the Ethics Committee of all involved institutions (Hospital Universitario Fundación Alcorcón 24-117, Universidad Rey Juan Carlos 010220240912024). All procedures will be conducted following the Declaration of Helsinki. Participants will be informed of the aims and procedures of the study and will receive the informed written consent which should be signed before their inclusion. Study results will be disseminated through peer-reviewed publications and presentations at scientific meetings. Fernández De Las Peñas C, Cigarán-Méndez M, Ambite-Quesada S, Gómez-Calero C, Fernández-Palacios FG, Pacho-Hernández JC, et al. Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: Protocol for a case-control study. BMJ Open . 2025;15(8). 2044-6055 10.1136/bmjopen-2025-103305 https://hdl.handle.net/20.500.14352/131842 2044-6055 https://doi.org/10.1136/BMJOPEN-2025-103305 https://bmjopen.bmj.com/content/15/8/e103305 Association of nociceptive, neurocognitive, psychological and genetic profile on conditioned pain modulation in women with migraine: protocol for a case–control study