2026-06-01T02:06:54Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1324602026-02-18T01:12:29Zcom_20.500.14352_14col_20.500.14352_15

Human germline genome editing: Is there room for reinterpreting Article 13 of the Oviedo Convention? Bernardo Álvarez, María Ángela Genome editing CRISPR Oviedo Convention Council of Europe Council of Europe Filosofía del Derecho Bioética (Filosofía) 56 Ciencias Jurídicas y Derecho 5602.03 Filosofía del Derecho 7199 Otras Especialidades Relacionadas Con la Ética Article 13 of the Oviedo Convention (the Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine) is a cornerstone of the legal regulation of human genome editing. However, the wording of this article is open to significant interpretation, particularly regarding the phrase 'genome of any descendants' and its application to germline interventions. This article analyses the interpretative difficulties of this provision and proposes a new interpretation, arguing that certain genetic interventions do not modify the genome of descendants per se, but rather manipulate the natural randomness. By analysingparadigmatic cases such as cystic fibrosis and Huntington's disease, the paper demonstrates that human genome editing could potentiallyproduce results that occur naturally with certain probabilities without introducing new gene variants. The paper concludes with proposals for regulatory reform to strengthen legal certainty in this area. Ministerio de Ciencia e Innovación Agencia Estatal de Investigación FEDER Depto. de Salud Pública y Materno - Infantil Fac. de Medicina TRUE pub 2026-02-17T07:42:53Z 2026-02-17T07:42:53Z 2026-02-16 journal article VoR https://hdl.handle.net/20.500.14352/132460 XXXX-XXXX 10.1344/rbd2026.66.51509 eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136743OB-I00/ES/EL DERECHO PENAL ANTE LOS RETOS ACTUALES DE LA BIOMEDICINA/ Bernardo Álvarez, M. Ángela. (2026). Human germline genome editing: Is there room for reinterpreting Article 13 of the Oviedo Convention? Revista De Bioética Y Derecho, (66), 77–88. https://doi.org/10.1344/rbd2026.66.51509 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ open access application/pdf Observatori de Bioètica i Dret