2026-06-29T09:25:29Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1328552026-02-24T01:20:17Zcom_20.500.14352_14col_20.500.14352_15

Silicon‐Enriched Restructured Meat Mitigates Metabolic Dysfunction‐Associated Steatohepatitis in a Late‐Stage Type 2 Diabetes Mellitus Rat Model Redondo‐Castillejo, Rocío Hernández Martín, Marina Bocanegra De Juana, Aranzazu Macho González, Adrián García Fernández, Rosa Ana Apaza Ticona, Luis Nestor Bastida Codina, Sara Sánchez Muniz, Francisco José López-Oliva Muñoz, María Elvira Garcimartín Álvarez, Alba Benedí González, Juana María 641 612.019 591.1 615.01/.03 ChREBP/SREBP‑1c signaling Antioxidant defenses Oxysterols Proliferation to apoptosis ratio; Silicon‐functional meat Dietética y nutrición (Farmacia) Farmacología (Farmacia) Fisiología animal (Farmacia) 3206 Ciencias de la Nutrición Functional foods with antidiabetic and lipid-lowering properties may serve as a nutritional strategy for metabolic dysfunction-associated steatohepatitis (MASH), especially when coexisting with type 2 diabetes mellitus (T2DM). This study evaluates whether the consumption of silicon-enriched restructured meat (Si-RM) could alleviate hepatic injury and metabolic disturbances in a late-stage T2DM rat model. Early-stage (ED, n = 8) and late-stage (LD, n = 16) T2DM were induced following a high-saturated-fat diet or a high-saturated-fat, high-cholesterol diet plus streptozotocin/nicotinamide injection, respectively, both diets containing a control meat. After confirming hyperglycemia, half of LD rats received Si-RM for 5 weeks (LD-Si, n = 8). Metabolic indices, liver histology, oxysterols, hepatic ChREBP/SREBP-1c, proliferation/apoptosis balance, and antioxidant defenses were assessed. LD rats developed clear histopathological and biochemical MASH. Si-RM consumption partially ameliorated these alterations, showing reduced lobular inflammation, improved serum oxysterol profile (decreased 25- and 27-hydroxycholesterols, increased 7-hydroxylated cholesterols), downregulated hepatic ChREBP, restored SREBP-1c, rebalanced proliferation to apoptosis ratio, and enhanced antioxidant defenses. Si-RM mitigated MASH severity and improved hepatic oxidative and metabolic status in a late-stage T2DM. These findings support the therapeutic potential of Si-RM as a promising and accessible nutritional adjuvant strategy against MASH Comunidad de Madrid Ministerio de Ciencia, Innovación y Universidades (España) Depto. de Fisiología Depto. de Farmacología y Toxicología Depto. de Nutrición y Ciencia de los Alimentos Depto. de Medicina y Cirugía Animal Depto. de Química en Ciencias Farmacéuticas Fac. de Farmacia Fac. de Veterinaria TRUE pub 2026-02-22T11:02:49Z 2026-02-22T11:02:49Z 2026 journal article VoR https://hdl.handle.net/20.500.14352/132855 1613-4125 10.1002/mnfr.70404 1613-4133 eng TEC 2024/BIO-307-BICAROBESITY-CM FPU20/02920 Redondo‐Castillejo R, Hernández‐Martín M, Bocanegra A, et al. Silicon‐Enriched Restructured Meat Mitigates Metabolic Dysfunction‐Associated Steatohepatitis in a Late‐Stage Type 2 Diabetes Mellitus Rat Model. Molecular Nutrition Food Res 2026;70:e70404. https://doi.org/10.1002/mnfr.70404 restricted access application/pdf Wiley