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   <dc:title>Reducing leads, enhancing wearable practicality: A comparative study of 3-lead vs. 12-lead ECG classification</dc:title>
   <dc:creator>González-Cabeza, Sergio</dc:creator>
   <dc:creator>Sanz-Guerrero, Mario</dc:creator>
   <dc:creator>Piñuel, Luis</dc:creator>
   <dc:creator>Buelga Suárez, Mauro Luis</dc:creator>
   <dc:creator>Alonso Salinas, Gonzalo Luis</dc:creator>
   <dc:creator>Diaz-Vicente, Marian</dc:creator>
   <dc:creator>Recas Piorno, Joaquín</dc:creator>
   <dc:subject>Deep learning</dc:subject>
   <dc:subject>Electrocardiography</dc:subject>
   <dc:subject>One-vs-All classification</dc:subject>
   <dc:subject>Reduced-lead ECG</dc:subject>
   <dc:subject>Transfer learning</dc:subject>
   <dc:subject>Informática (Informática)</dc:subject>
   <dc:subject>33 Ciencias Tecnológicas</dc:subject>
   <dc:description>Inspired by recent advances in clinical research and the growing adoption of wearable ECG devices, this study explores the feasibility of using reduced-lead ECGs for automated detection of heart anomalies using deep learning, providing a more accessible and cost-effective alternative to traditional 12-lead ECGs. This research adapts and evaluates a state-of-the-art 12-lead deep learning model (from Ribeiro et al. [1]) for 3-lead configurations. The 12-lead ECG model architecture was trained from scratch on the public database PTB-XL. It was then modified to use 3 leads by only changing the input layer. Despite a 75% reduction in input data, the 3-lead model showed only a subtle 3% performance drop. To address this gap, the 3-lead model was further optimized using a novel strategy that combines transfer learning and a One-vs-All classification approach. Using PTB-XL's five-class setup (normal vs. four pathologies: myocardial infarction, ST/T change, conduction disturbance, and hypertrophy), we report the micro-averaged F1-score across all test samples. The new optimized 3-lead model achieves a global (micro-averaged) F1-score of 77% (vs. 78% for the 12-lead model). These findings highlight the potential of simplified and cost-effective reduced-lead classification models to deliver near-equivalent diagnostic accuracy. This advancement could democratize access to early cardiac diagnostics, particularly in resource-limited settings.</dc:description>
   <dc:description>Depto. de Arquitectura de Computadores y Automática</dc:description>
   <dc:description>Fac. de Informática</dc:description>
   <dc:description>TRUE</dc:description>
   <dc:description>pub</dc:description>
   <dc:date>2026-02-23T15:30:31Z</dc:date>
   <dc:date>2026-02-23T15:30:31Z</dc:date>
   <dc:date>2025</dc:date>
   <dc:type>journal article</dc:type>
   <dc:type>AM</dc:type>
   <dc:identifier>https://hdl.handle.net/20.500.14352/132929</dc:identifier>
   <dc:identifier>XXXX-XXXX</dc:identifier>
   <dc:identifier>10.1016/j.medengphy.2025.104419</dc:identifier>
   <dc:language>eng</dc:language>
   <dc:rights>metadata only access</dc:rights>
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