2026-06-29T01:20:37Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1334942026-02-27T13:14:14Zcom_20.500.14352_14col_20.500.14352_15

MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore Avendaño López, María Carmen Caballero, Esmeralda Mendez-Vidal, Cristina Quesada, Ana R. de Menéndez Ramos, José Carlos The MDR chemosensitising activity of several analogues of the ardeemins, including five derivatives of the ABCD fragment, nine derivatives of the complete hexacyclic framework and one seco analogue lacking the B ring was studied. The results obtained confirm that the pharmacophoric moiety of the ardeemins as MDR reversers is located at their DEF fragment, and suggest that the epimer of the ardeemins at the alanine stereocenter should be more active than the natural stereoisomer. 2026-02-27T13:14:14Z 2026-02-27T13:14:14Z 2026-02-27T13:14:14Z 2006 journal article https://hdl.handle.net/20.500.14352/133494 1570-1808 10.2174/157018006777805558 1875-628X eng metadata only access Bentham Science Publishers