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00925njm 22002777a 4500 dc Román, Elvira author Correia, C. Inês Ribeiro author Alonso Monge, Rebeca María Del Mar author Prieto Prieto, Antonio Daniel author Pla Alonso, Jesús author 2019-03-14 In 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide range of stress conditions frequently encountered by fungi in their common habitats. MAPK signaling is initiated at the plasma membrane, where triggering stimuli lead to a phosphorylation cascade that ultimately activates transcription factors to ensure an appropriate adaptive response. In pathogenic fungi, the HOG pathway gains special significance as it is involved in traits related to pathogenicity; these include biofilm formation, adhesion to surfaces, and morphogenetic and epigenetic transitions. It also plays a role in controlling both the pathogen and the commensal state program. Understanding the signals leading to its activation, the elements of the pathways and the targets of the pathway are therefore of primary importance in the design of novel antifungals. Román, E., Correira, C. I. R., Alonso Monge, R. M. M. et al. «The HOG MAPK Pathway in Candida Albicans: More than an Osmosensing Pathway». International Microbiology, vol. 23, n.o 1, enero de 2020, pp. 23-29. DOI.org (Crossref), https://doi.org/10.1007/s10123-019-00069-1. 1618-1905 10.1007/s10123-019-00069-1 https://hdl.handle.net/20.500.14352/13367 https//doi.org/10.1007/s10123-019-00069-1 https://link.springer.com/ The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway.