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Sorrells, Shawn Caso Fernández, Javier Rubén Munhoz, Carolina Sapolsky, Robert 2026-03-26T13:11:10Z 2026-03-26T13:11:10Z 2009-10-15 Sorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009). The stressed CNS: when glucocorticoids aggravate inflammation. Neuron, 64(1), 33–39. https://doi.org/10.1016/j.neuron.2009.09.032 0896-6273 10.1016/j.neuron.2009.09.032 https://hdl.handle.net/20.500.14352/134344 1097-4199 https://doi.org/10.1016/j.neuron.2009.09.032 https://www.sciencedirect.com/science/article/pii/S0896627309007430?via%3Dihub Glucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite direction. The CNS is a particularly interesting example, both because of its unique immune environment, and because GCs affect immune responses differently in different brain regions. In this minireview we discuss the contexts wherein GCs increase CNS inflammation and point out directions for future investigation. eng restricted access The Stressed CNS: When Glucocorticoids Aggravate Inflammation journal article