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Soluble defense collagens: sweeping up immune threats Casals Carro, María Cristina García-Fojeda, Belén Minutti, Carlos M. 577.112.828 Collectins Ficolins C1q Adiponectin Efferocytosis Tissue repair Bioquímica (Biología) 2302 Bioquímica Soluble defense collagens form a group of secreted proteins that are primarily involved in host defense. All defense collagens contain a globular recognition domain contiguous to a collagen-like triple helical domain. They are oligomeric proteins, assembled in multiples of three subunits due to their collagen domains. Members of this group include collectins such as surfactant protein A and D (SP-A, SP-D), and mannan-binding lectin; C1q, the first component of the complement system; adiponectin; and ficolins. All are secreted to tissue cavities or serum. Soluble defense collagens are specialized to respond to infection, triggering the initiation of the complement cascade and/or enhancing phagocytosis of pathogens by macrophages. However, once inflammation is established, C1q, collectins, ficolins, or adiponectin can influence macrophage responses, thereby contributing to resolve the inflammation. In addition, some members of this group of proteins (SP-A, C1q, and adiponectin) modulate tissue-repair functions of macrophages. This review will focus on the molecular mechanisms by which these proteins efficiently defend against immune threats and contribute to tissue repair. Ministerio de Ciencia e Innovación (España) Instituto de Salud Carlos III (España) Sección Deptal. de Bioquímica y Biología Molecular (Biológicas) Fac. de Ciencias Biológicas TRUE pub 2023-06-17T13:26:09Z 2023-06-17T13:26:09Z 2019-08 journal article https://hdl.handle.net/20.500.14352/13474 0161-5890, ESSN: 1872-9142 10.1016/j.molimm.2019.06.007 eng info:eu-repo/grantAgreement/MINECO//SAF2015-65307-R/ES/FACTORES ANTI-INFECCIOSOS DEL PULMON COMO NUEVAS ESTRATEGIAS TERAPEUTICAS FRENTE A INFECCIONES RESPIRATORIAS/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094355-B-I00/ES/SEÑALES ESPECIFICAS DE TEJIDO QUE MODULAN RESPUESTAS TIPO 2 EN MACROFAGOS ALVEOLARES EN SALUD Y ENFERMEDAD/ info:eu-repo/grantAgreement/MSC//CB06%2F06%2F0002/ES/Enfermedades respiratorias 2/ Casals C, García-Fojeda B, Minutti CM. Soluble defense collagens: Sweeping up immune threats. Molecular Immunology 2019; 112: 291–304. [DOI: 10.1016/j.molimm.2019.06.007] Atribución-NoComercial-SinDerivadas 3.0 España https://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access application/pdf Elsevier