2026-06-28T10:35:46Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1364342026-04-29T23:53:02Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Arias Álvarez, María author Alfonso Gutiérrez-Adan author Eva Pericuesta author Bermejo Álvarez, Pablo author Millán Pastor, María Pilar author María Rodríguez author Lorenzo González, Pedro Luis author Pilar García Rebollar author García García, Rosa María 2026-04-29T13:53:15Z 2026-04-29T13:53:15Z 2026 Arias-Alvarez, M., Gutiérrez-Adan, A., Pericuesta, E., Bermejo-Alvarez, P., Millán, P., Rodríguez, M., Lorenzo, P. L., Rebollar, P. G., & García-García, R. M. (2026). Maternal undernutrition reprograms reproductive and metabolic phenotypes in female offspring of the rabbit model. PloS one, 21(3), e0345066. https://doi.org/10.1371/journal.pone.0345066 https://doi.org/10.1371/journal.pone.0345066 https://hdl.handle.net/20.500.14352/136434 1932-6203 https://doi.org/10.1371/journal.pone.0345066 41886523 https://pubmed.ncbi.nlm.nih.gov/41886523/ Maternal undernutrition during pregnancy in mammals can induce long-term effects in offspring health through molecular programming of the gametes. Using the rabbit model, this study investigates whether maternal food restriction (FR) during the first two-thirds of gestation induces effects on ovarian follicular, oocyte, and early embryo developmental markers in F1 female offspring at the onset of reproductive life. Additionally, body composition, metabolic profile, and growth trajectory from birth to sexual maturity (16 weeks) were assessed to evaluate potential impacts on overall health. Pregnant females (F0) were fed either ad libitum (Control group) or a restricted diet covering 60% of nutritional requirements (FR group). Offspring from both groups were fed ad libitum. Maternal FR had no significant effects on birth weight and survival of progeny, growth trajectory, feed intake or glycemic profile during the juvenile phase. Body weight, body composition, lipid, and glycemic profiles in F1 sexually mature females were similar. However, serum aminotransferase levels were significantly elevated in the F1 females from FR group (P<0.05) Serum anti-Müllerian hormone levels, ovulation rate, apoptosis rate, and in vitro embryo development did not differ between groups. These findings suggest that re-feeding after maternal food restriction can attenuate adverse long-term effects on offspring growth and metabolism, while modulating the expression of genes related to oxidative stress, apoptosis and fatty acid uptake in the oocytes of F1 females. This modulation may reflect the activation of compensatory intracellular mechanisms that support early embryonic development in juvenile females at the onset of their reproductive life eng Attribution 4.0 International Maternal undernutrition reprograms reproductive and metabolic phenotypes in female offspring of the rabbit model journal article 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URL https://docta.ucm.es/bitstreams/6ffd21cb-4829-4ad0-a772-e5f406439af5/download File MD5 fa7cb2cb8e317e60b35c646735f98ddb 1724989 application/pdf Arias-Alvarez_PLOSOne_2026.pdf