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00925njm 22002777a 4500 dc Baselga Cervera, Beatriz author García Balboa, María Del Camino author López Rodas, Victoria author Fernández Díaz, Marta author Costas Costas, Eduardo author 2019 Resulting from the nuclear fuel cycle, large amounts of depleted uranium (DU) tails are piling up, waiting for possible use or final disposal. To date, the recovery of the residual 235U isotope contained in DU has been conducted only marginally by physical processes. Relative isotope abundances are often mediated by biological processes, and the biologically driven U isotopic fractionation has been previously identified in reducing bacteria. Our results indicate that the cells of two microalgal strains (freshwater Chlamydomonas sp. (ChlGS) and marine Tetraselmis mediterranea (TmmRU)) took up DU from the exposure solutions, inducing U isotopic fractionation with a preference for the fissile 235U isotope over 238U. The n(235U)/n(238U) isotopic fractionation magnitudes (δ235) were 23.6 ± 12.5‰ and 370.4 ± 103.9‰, respectively. These results open up new perspectives on the re-enrichment of DU tailings, offering a potential biological alternative to obtain reprocessed natural-equivalent uranium. Additionally, the findings present implications for identifying biological signatures in the geologic records Baselga-Cervera, B., García-Balboa, C., López-Rodas, V., Fernández Díaz, M., & Costas, E. (2019). Evidence of microalgal isotopic fractionation through enrichment of depleted uranium. Scientific Reports, 9(1), 1973. https://doi.org/10.1038/s41598-019-38740-2 10.1038/s41598-019-38740-2 https://hdl.handle.net/20.500.14352/136546 2045-2322 https://doi.org/10.1038/s41598-019-38740-2 https://doi.org/10.1038/s41598-026-47799-7 Evidence of microalgal isotopic fractionation through enrichment of depleted uranium Correction: Evidence of microalgal isotopic fractionation through enrichment of depleted uranium