2026-06-29T16:48:32Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1368962026-05-26T00:00:51Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Marques Coelho, Carina author de la Fuente Fernández, Pablo author Bononad, Paula author Viñals, Sílvia author Tavares de Sousa, Célia author Galaviz, Daniel author Herrera, Federico author del Monte-García, Inés author Sánchez Parcerisa, Daniel author Cortés-Llanos, Belén author 2026-04-15 Objective. To develop and optimise a dedicated low-energy proton beamline at the Centre for Micro-Analysis of Materials (CMAM, Madrid, Spain) for radiobiological applications. Approach. An automated irradiation system was implemented, integrating Gafchromic EBT3 radiochromic film dosimetry corrected for linear energy transfer dependent quenching and post-irradiation darkening. Dosimetric calibration was performed using multichannel analysis, and beam performance was systematically evaluated as a function of distance, raster scanning area, beam intensity and reproducibility. Main results. Optimal operating conditions were identified at moderate beam currents (⩽1nA) and scanning areas of 40 × 40 to 50 × 50mm2, yielding homogeneous dose distributions with reproducibility better than 8%. The dosimetric protocol demonstrated linearity across clinically relevant dose ranges and allowed a reliable correlation between irradiation parameters and absorbed dose. Proof-of-concept experiments on U-87 MG glioblastoma cells confirmed the system’s ability to deliver controlled and biologically effective proton exposures, as demonstrated by clonogenic survival assays. Significance. These results establish the CMAM implantation beamline as a robust and versatile platform for preclinical proton radiobiology, providing accurate dosimetric control and supporting investigations of relative biological efficacy. The system facilitates translational advances in proton radiobiology, bridging physical and biological studies in low-energy proton irradiation. Marques Coelho, Carina, et al. «Development and characterisation of a radiobiology proton beamline using radiochromic film dosimetry». Physics in Medicine & Biology, vol. 71, n.o 8, abril de 2026, p. 085003. DOI.org (Crossref), https://doi.org/10.1088/1361-6560/ae5457. 0031-9155 10.1088/1361-6560/ae5457 https://hdl.handle.net/20.500.14352/136896 1361-6560 https://dx.doi.org/10.1088/1361-6560/ae5457 https://iopscience.iop.org/article/10.1088/1361-6560/ae5457 Development and characterisation of a radiobiology proton beamline using radiochromic film dosimetry