2026-06-28T20:05:04Zhttps://docta.ucm.es/rest/oai/request
oai:docta.ucm.es:20.500.14352/1371362026-06-03T23:53:00Zcom_20.500.14352_14col_20.500.14352_15
Docta Complutense author Calleja Conde, Javier author Echeverry Alzate, Víctor author Sanz SanCristobal, Marina author Alonso Gil, Sandra author Giné Domínguez, Elena author Buhler, Kora Mareen Katharina author López Moreno, José Antonio author Pérez Castillo, Ana author Morales García, José Ángel 2026-06-03T10:25:17Z 2026-06-03T10:25:17Z 2026-05-12 Javier Calleja-Conde, Víctor Echeverry-Alzate, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Elena Giné, Kora Bühler, Jose A. López-Moreno, Ana Perez-Castillo, José A. Morales-García, Therapeutic properties of ayahuasca component N,N-Dimethyltryptamine in a pre-clinical model of Parkinson's disease, Experimental Neurology, Volume 403, 2026, 115822, ISSN 0014-4886, https://doi.org/10.1016/j.expneurol.2026.115822. 0014-4886 10.1016/j.expneurol.2026.115822 https://hdl.handle.net/20.500.14352/137136 https://doi.org/10.1016/j.expneurol.2026.115822 https://www.sciencedirect.com/science/article/pii/S001448862600186X Parkinson's disease is a progressive neurodegenerative disorder with increasing global prevalence, primarily driven by population ageing. A hallmark of the disease is the degeneration of nigrostriatal dopaminergic neurons, accompanied by marked activation of glial cells and a sustained neuroinflammatory response. Current pharmacological treatments are limited to symptomatic relief and do not halt or reverse disease progression. Ayahuasca, a traditional Amazonian psychoactive brew, has attracted growing scientific interest for its potential therapeutic effects in neuropsychiatric and neurodegenerative conditions. Its principal psychoactive compound, N,N-dimethyltryptamine (DMT), acts as an agonist at the 5-HT2A serotonin receptor—responsible for its hallucinogenic properties—and at the sigma-1 receptor, a molecular target implicated in neuroprotection and modulation of inflammation. This study investigates the neuroprotective and anti-inflammatory potential of DMT in a preclinical model of Parkinson's disease. Our findings demonstrate that DMT administration results in molecular changes within the nigrostriatal pathway consistent with reduced neuroinflammation and neuronal preservation. Furthermore, behavioral assessments indicate symptomatic improvements following treatment. These results support the therapeutic potential of DMT as a disease-modifying agent in Parkinson's disease and warrant further investigation. eng Therapeutic properties of ayahuasca component N,N-Dimethyltryptamine in a pre-clinical model of Parkinson's disease journal article 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URL https://docta.ucm.es/bitstreams/8e339d21-cefd-4b67-a77c-1ce1be0d03ed/download File MD5 7a6213b278c3f41232aa50eaf88d027e 16010066 application/pdf CallejaConde_etAl_ExperimentalNeurology_2026.pdf