2026-06-28T14:54:56Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1378132026-06-25T17:00:51Zcom_20.500.14352_14col_20.500.14352_15

The lung (surfing) dealer: pulmonary surfactant and drug delivery Cañadas Benito, Olga Hidalgo, Alberto Pérez Gil, Jesús Introduction The pulmonary route is an attractive route for drug delivery due to its large surface area, extensive vascularization, and avoidance of hepatic first-pass metabolism. Nevertheless, reaching alveolar regions typically requires a complex balance of aerodynamic particle size, airway geometry, patient cooperation and ventilatory capacity. Areas covered Research during two decades has pursued the potential use of pulmonary surfactant, the lipid-protein complex that lines and stabilizes the respiratory air–liquid interface, as drug delivery agent. Lung surfactant may incorporate and solubilize hydrophobic drugs, which could then be delivered into the airways as part of surfactant-based liposomes or nanoparticles. In this review, we summarize recent advances as they have reframed the air–lung lining fluid interface to open the innovative concept of interfacial delivery: drugs could actively spread over the respiratory surface, driven by interfacial forces such as those defining pulmonary surfactant action. Literature included in this review was systematically searched in PubMed, Scopus and Google Scholar using targeted keyword combinations. Expert opinion Key knowledge gaps and technological challenges are identified whose investigation will contribute to develop the full potential of PS-based inhalation delivery strategies. 2026-06-25T17:00:51Z 2026-06-25T17:00:51Z 2026-03 journal article Cañadas, O., Hidalgo, A., & Pérez-Gil, J. (2026). The lung (surfing) dealer: pulmonary surfactant and drug delivery. Expert Opinion on Drug Delivery, 23(6), 1019–1029. https://doi.org/10.1080/17425247.2026.2646545 1742-5247 10.1080/17425247.2026.2646545 https://hdl.handle.net/20.500.14352/137813 1744-7593 https://doi.org/10.1080/17425247.2026.2646545 https://www.tandfonline.com/doi/full/10.1080/17425247.2026.2646545?scroll=top&needAccess=true eng info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2027/PID2024-156556OB-I00/ES/NUEVAS HERRAMIENTAS BIO(NANO)TECNOLOGICAS Y BIOFISICAS PARA DECODIFICAR Y REGENERAR EL HUB DEL SISTEMA SURFACTANTE PULMONAR HACIA NUEVAS TERAPIAS RESPIRATORIAS (PULMODECODE)/ metadata only access Taylor and Francis