2026-06-29T09:28:27Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/138342023-08-26T06:47:08Zcom_20.500.14352_14col_20.500.14352_15
The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis
Wijnker, Erik
Harashima, Hirofumi
Müller, Katja
Parra Núñez, Pablo
Bastiaan de Snoo, C.
Van de Belt, José
Dissmeyer, Nico
Bayer, Martin
Pradillo Orellana, Mónica
Schnittger, Arp
581.15
Meiosis
Cyclin-dependent kinase
Cross-over interference
Class I crossovers
Meiotic recombination
Botánica (Biología)
Genética
2417.03 Botánica General
2409 Genética
Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.
Unión Europea. FP7
Ministerio de Ciencia e Innovación (MICINN)
European Molecular Biology Organization
Depto. de Genética, Fisiología y Microbiología
Fac. de Ciencias Biológicas
TRUE
pub
2023-06-17T13:36:08Z
2023-06-17T13:36:08Z
2019-06
journal article
https://hdl.handle.net/20.500.14352/13834
0027-8424, ESSN: 1091-6490
10.1073/pnas.1820753116
eng
COMREC (606956)
AGL2015-67349-P
ALTF 679-2013
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
open access
application/pdf
National Academy of Sciences