2026-07-24T07:59:17Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/1386672026-07-17T23:54:53Zcom_20.500.14352_14col_20.500.14352_15

00925njm 22002777a 4500 dc Liu, A author Zhou, K author Martínez Caballero, María Aranzazu author López Torres, Bernardo author Martínez Caballero, Marta author Martínez Larrañaga, María Rosa author Wang, X author Anadón Navarro, Arturo Ramón author Ares Lombán, Irma author 2021 RASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a "Janus" in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. The participation of RASSF4 in the regulation of intracellular store-operated Ca2+ entry also affects cell survival. Moreover, the mechanism of inducing abnormal expression of RASSF4 was summarized. We highlight recent advances in our knowledge of RASSF4 function in the development of cancer and other clinical diseases, which may provide insight into the controversial functions of RASSF4 and its potential application in disease therapy Liu, A., Zhou, K., Martínez, M. A., Lopez-Torres, B., Martínez, M., Martínez-Larrañaga, M. R., Wang, X., Anadón, A., & Ares, I. (2022). A "Janus" face of the RASSF4 signal in cell fate. Journal of cellular physiology, 237(1), 466–479. https://doi.org/10.1002/jcp.30592 0021-9541 10.1002/jcp.30592 https://hdl.handle.net/20.500.14352/138667 1097-4652 https://doi.org/10.1002/jcp.30592 34553373 A “Janus” face of the RASSF4 signal in cell fate