2026-07-23T05:35:00Zhttps://docta.ucm.es/rest/oai/requestoai:docta.ucm.es:20.500.14352/1386672026-07-17T23:54:53Zcom_20.500.14352_14col_20.500.14352_15
A “Janus” face of the RASSF4 signal in cell fate
Liu, A
Zhou, K
Martínez Caballero, María Aranzazu
López Torres, Bernardo
Martínez Caballero, Marta
Martínez Larrañaga, María Rosa
Wang, X
Anadón Navarro, Arturo Ramón
Ares Lombán, Irma
636.09:615.9
Cell death
Cell survival
DNA methylation
RASSF4
Signaling pathways
Toxicología (Farmacia)
3214 Toxicología
.
RASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a "Janus" in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. The participation of RASSF4 in the regulation of intracellular store-operated Ca2+ entry also affects cell survival. Moreover, the mechanism of inducing abnormal expression of RASSF4 was summarized. We highlight recent advances in our knowledge of RASSF4 function in the development of cancer and other clinical diseases, which may provide insight into the controversial functions of RASSF4 and its potential application in disease therapy
National Key R & D Program of China
Ministerio de Ciencia, Innovación y Universidades ( España)
Depto. de Farmacología y Toxicología
Fac. de Veterinaria
TRUE
pub
2026-07-17T08:56:42Z
2026-07-17T08:56:42Z
2021
journal article
VoR
https://hdl.handle.net/20.500.14352/138667
0021-9541
10.1002/jcp.30592
1097-4652
eng
2018YFC1603005
2662020DKPY020
PID 2020‐ 115979RR‐C33
Liu, A., Zhou, K., Martínez, M. A., Lopez-Torres, B., Martínez, M., Martínez-Larrañaga, M. R., Wang, X., Anadón, A., & Ares, I. (2022). A "Janus" face of the RASSF4 signal in cell fate. Journal of cellular physiology, 237(1), 466–479. https://doi.org/10.1002/jcp.30592
restricted access
application/pdf
Wiley