2026-06-28T10:12:02Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/178262023-08-10T23:46:37Zcom_20.500.14352_14col_20.500.14352_15

Estimation of genetic purging under competitive conditions López-Cortegano, Eugenio Vilas, Ana Caballero, Armando García-Dorado, Aurora Inbreeding depression for fitness traits is a key issue in evolutionary biology and conservation genetics. The magnitude ofinbreeding depression, though, may critically depend on the efficiency of genetic purging, the elimination or recessive deleteriousmutations by natural selection after they are exposed by inbreeding. However, the detection and quantification of genetic purgingfor nonlethal mutations is a rather difficult task. Here, we present two comprehensive sets of experiments with Drosophila aimedat detecting genetic purging in competitive conditions and quantifying its magnitude. We obtain, for the first time in competitiveconditions, an estimate for the predictive parameter, the purging coefficient (d), that quantifies the magnitude of genetic purging,either against overall inbreeding depression (d  0.3), or against the component ascribed to nonlethal alleles (dNL 0.2). We findthat competitive fitness declines at a high rate when inbreeding increases in the absence of purging. However, in moderate sizepopulations under competitive conditions, inbreeding depression need not be too dramatic in the medium to short term, as theefficiency of purging is also very high. Furthermore, we find that purging occurred under competitive conditions also reduced theinbreeding depression that is expressed in the absence of competition. 2023-06-17T21:56:44Z 2023-06-17T21:56:44Z 2023-06-17T21:56:44Z 2016-08 journal article https://hdl.handle.net/20.500.14352/17826 0014-3820, ESSN: 1558-5646 10.1111/evo.12983 eng CGL2014-53274-P, CGL2012-39861-C02-01 GPC2013-011 BES-2012-055006, BES-2010-032537 restricted access Wiley