2026-06-27T01:02:31Zhttps://docta.ucm.es/rest/oai/request

oai:docta.ucm.es:20.500.14352/178382024-09-04T15:32:16Zcom_20.500.14352_14col_20.500.14352_15

Bari, Alessandra Bloise, Nora Fiorilli, Sonia Novajra, Giorgia Vallet Regí, María Dulce Nombre Brunni, Giovanna Torres Pardo, María De La Almudena González Calbet, José María Visai, Libia Vitale-Brovarone, Chiara 2023-06-17T21:57:07Z 2023-06-17T21:57:07Z 2017-04-12 Bari, A., Bloise, N., Fiorilli, S. et al. «Copper-Containing Mesoporous Bioactive Glass Nanoparticles as Multifunctional Agent for Bone Regeneration». Acta Biomaterialia, vol. 55, junio de 2017, pp. 493-504. DOI.org (Crossref), https://doi.org/10.1016/j.actbio.2017.04.012. 1742-7061 10.1016/j.actbio.2017.04.012 https://hdl.handle.net/20.500.14352/17838 https://doi.org/10.1016/j.actbio.2017.04.012 The application of mesoporous bioactive glasses (MBGs)containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure. The Cucontaining MBG (2% mol.) showed high exposed surface area (550 m2 g-1), uniform mesoporous channels (2.6 nm), remarkable in vitro bioactive behaviour and sustained release of Cu2+ ions. Cu-MBG nanoparticles and their ionic dissolution extracts exhibited antibacterial effect against three different bacteria strains, E. coli, S. aureus, S. epidermidis, and the ability to inhibit and disperse the biofilm produced by S. epidermidis. The obtained results suggest that the developed material, which combines in single multifunctional agent excellent bioactivity and antimicrobial ability, offers promising opportunities for the prevention of infectious diseases and the effective treatment of bone defects. eng open access Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration journal article